Sports Nutrition — all lessons

Evidence-based supplements (creatine, caffeine and others)

Which supplements have strong evidence for performance — creatine, caffeine, nitrate, beta-alanine, bicarbonate — with doses, uses, side effects and the IOC framework.

Intermediate Evidence: Strong evidence 3 min read Reviewed 2026-10-31 Status: draft

Learning objectives

  • Apply a framework for evaluating supplements
  • Describe the evidence, dosing and uses of the main performance supplements
  • Identify side effects and individual variability
  • Integrate supplements responsibly after food and training

Before this lesson

Why this matters

Supplements are heavily marketed, but only a few have good evidence. Knowing them — and their limits — saves clients money and risk.

A framework

The IOC consensus asks: Is it safe? Is it effective for this athlete and event? Is it legal and free of contamination risk? Is it worth it after diet, training and sleep are optimised? [maughan2018]

Supplements with strong evidence

SupplementTypical protocolBenefitsNotes
Caffeine3–6 mg/kg ~60 min before [guest2021]Endurance, team sport, strength, alertnessSleep disruption, anxiety; responses vary
Creatine monohydrate3–5 g/day (or 20 g/day × 5–7 days load) [kreider2017]Repeated sprints, strength/hypertrophy with training~1–2 kg water gain
Dietary nitrate~5–9 mmol (≈ 300–600 mg) 2–3 h beforeEconomy, some endurance/team tasksSmaller effects in elite
Beta-alanine~3–6 g/day split, for ≥4 weeksEfforts ~30 s–10 minTingling (paraesthesia)
Sodium bicarbonate0.2–0.3 g/kg 60–180 min beforeHigh-intensity efforts 1–7 minGI distress common

Protocols summarised from the IOC consensus [maughan2018].

Common mistakes and misconceptions

Case study

A 70 kg rower trials caffeine at 3 mg/kg (210 mg) 60 min before ergometer tests, improving 2,000 m time by ~1% without sleep problems when used before morning tests only.

Further learning: video lessons

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Knowledge check

Knowledge check · 0/5

1. A common effective caffeine dose for performance is…

Answer B. ISSN position stand.

2. Creatine is most useful for…

Answer B. Increases muscle PCr.

3. Beta-alanine improves performance mainly in efforts lasting about…

Answer B. Increases muscle carnosine buffering capacity.

4. Dietary nitrate (e.g., beetroot juice) may improve…

Answer B. Effects are smaller in highly trained athletes.

5. A common side effect of sodium bicarbonate is…

Answer A. GI upset is common; trial protocols carefully.

Short-answer & application questions

  1. Evaluate a pre-workout product label against the evidence.
  2. Plan caffeine use for a morning race for a caffeine-sensitive athlete.
  3. Explain creatine loading vs daily dosing.

Key takeaways

  • Supplements should come after a sound diet, training and sleep.
  • Strong evidence supports caffeine, creatine, dietary nitrate, beta-alanine and sodium bicarbonate for specific contexts.
  • Doses and protocols matter; individual responses vary and side effects exist.
  • Use third-party tested products to reduce contamination risk.

Connected topics

This is the canonical lesson for: Lifestyle Nutrition → Supplements & Practical Applications

References

  1. Maughan RJ, Burke LM, Dvorak J, et al. (2018). IOC consensus statement: dietary supplements and the high-performance athlete. British Journal of Sports Medicine, 52(7):439–455. doi:10.1136/bjsports-2018-099027 Guideline check pending
  2. Guest NS, VanDusseldorp TA, Nelson MT, et al. (2021). International Society of Sports Nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1):1. doi:10.1186/s12970-020-00383-4 Position stand check pending
  3. Kreider RB, Kalman DS, Antonio J, et al. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14:18. doi:10.1186/s12970-017-0173-z Position stand check pending

Educational content only — not medical advice. Consult a qualified clinician for diagnosis or treatment.