Hybrid Training — all lessons

Why “strength vs endurance” is outdated: the interference effect

The interference effect from Hickson (1980) to modern meta-analyses — what interferes, how much, the molecular story, and how to minimise it.

Intermediate Evidence: Strong evidence 3 min read Reviewed 2026-10-31 Status: draft

Learning objectives

  • Describe the original interference findings
  • Summarise modern evidence on concurrent training
  • Explain proposed molecular mechanisms and their limits
  • Apply strategies to minimise interference

Before this lesson

Why this matters

Fear of interference makes some lifters avoid cardio. The real picture is more reassuring.

The original finding

Hickson (1980): heavy strength training plus high-volume endurance training → strength gains plateaued after several weeks [hickson1980].

Modern evidence

FindingSource
Hypertrophy and maximal strength largely unaffected; explosive strength may be blunted[schumann2022]
Interference greater with running, high frequency and long duration[wilson2012]

Mechanisms

Endurance signalling (AMPK) may inhibit growth signalling (mTOR), but this is an oversimplification; fatigue, glycogen and total load also matter [fyfe2014].

Minimise interference

  • Separate sessions (≥6 h if possible) [fyfe2014]
  • Prioritise the session matching your main goal
  • Use cycling or low-impact cardio when strength is priority
  • Fuel and sleep well

Common mistakes and misconceptions

Case study

A bodybuilder fears cardio. His coach adds three 30-minute cycling sessions on separate days; over 16 weeks, his lean mass and strength continue to rise while his fitness improves.

Further learning: video lessons

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Knowledge check

Knowledge check · 0/5

1. Hickson’s (1980) study found…

Answer B. Classic study.

2. Schumann et al. (2022) concluded concurrent training…

Answer B. Updated meta-analysis.

3. Wilson et al. (2012) found more interference with…

Answer B. Modality and dose matter.

4. The AMPK–mTOR explanation is…

Answer B. Fyfe et al. (2014).

5. A strategy to reduce interference is…

Answer B. Spacing and dose.

Short-answer & application questions

  1. Explain the interference effect to a client.
  2. List programme changes that reduce interference.
  3. Critique the AMPK–mTOR model.

Key takeaways

  • Hickson (1980) showed strength gains plateaued when heavy endurance training was added.
  • Modern meta-analyses show little interference with hypertrophy or maximal strength; explosive strength may be modestly affected.
  • Interference increases with high endurance volume, running and frequency.
  • Molecular explanations (AMPK vs mTOR) are oversimplified.

Connected topics

References

  1. Hickson RC (1980). Interference of strength development by simultaneously training for strength and endurance. European Journal of Applied Physiology, 45(2–3):255–263. Classic study check pending
  2. Schumann M, Feuerbacher JF, Sünkeler M, et al. (2022). Compatibility of concurrent aerobic and strength training for skeletal muscle size and function: an updated systematic review and meta-analysis. Sports Medicine, 52(3):601–612. Meta-analysis check pending
  3. Wilson JM, Marin PJ, Rhea MR, et al. (2012). Concurrent training: a meta-analysis examining interference of aerobic and resistance exercises. Journal of Strength and Conditioning Research, 26(8):2293–2307. Meta-analysis check pending
  4. Fyfe JJ, Bishop DJ, Stepto NK (2014). Interference between concurrent resistance and endurance exercise: molecular bases and the role of individual training variables. Sports Medicine, 44(6):743–762. Narrative review check pending

Educational content only — not medical advice. Consult a qualified clinician for diagnosis or treatment.